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KMID : 0043319940170030194
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Archives of Pharmacal Research
1994 Volume.17 No. 3 p.194 ~ p.198
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Antitumor Effect Of Bismuth-conjugated Anti-IL-2R Monoclonal Antibody(2E4) on a IL-2 Receptor Positive Tumor EL4J3.4
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Kim Sung-Hoon
Kozak Robert-W.
Chung Kyeong-Soo
Ahn Byung-Zun
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Abstract
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The antitumor effects of the 2E4 and anti--Tac, monoclonal antibodies directed to Il-2 receptor (IL-2R) conjugated with .alpha.-particle emitting radionuclide bismuth-212., were compared. The demonstratedspecific cytotocicity to EL4J3, 4, a I cell line, than to EL4J, a cell line in thymidine incorporation assy. TEX>$^{212}Bi-2E4$ exerted the maximal antitumor effect in that % T/C in C57BL/6 mice implanted with EL4J3.4 ascitic tumor was 331% at the concentration of , while that of was 258% at .
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KEYWORD
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Antitumor effect, IL-2 receptor-derected monoclonal antibocies, EL4J, ELJ3, 4
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